What is capsicum spray? Better known as pepper spray or mace, capsicum spray is actually the active ingredient in these popular and effective self defense sprays. Oleoresin capsicum (OC) is a naturally occurring substance derived from hot peppers. OC Pepper causes an intense burning sensation to the skin, eyes and throat upon contact. Upon contact with eyes, nose, mouth or respiratory system and mucous membranes, the active ingredients in the pepper spray will cause eyes to slam shut, coughing, and an intense burning sensation to the skin. Effects should lessen in approximately 45 minutes. Capsicum spray or pepper spray is available in many different brands, formulations and spray patterns. Our most popular brands include Fox Labs Defense Spray, SABRE, Wildfire and Defense Technology.